Volume: 5   Issue: 10

Tukur Zayyanu, Karnawat Monika, Fatima Aliyu, Fatima Aliyu.
Canadian Journal of Discovery, 5(10), 1-13
doi: https://doi.org/10.5281/zenodo.14013684
Abstract: Introduction: Encapsulating of curcumin in calcium phosphate nanoparticles will boost its antioxidant potential while simultaneously lowering oxidative stress. Molecules having at least one oxygen atom and one or more unpaired electrons that are capable of independent living are known as reactive oxygen species. Free oxygen radicals such as singlet oxygen, hydroperoxyl radical, hydroxyl radical, superoxide anion radical, and free nitrogen radicals fall under this group. Aerobic respiration and the inflammatory response, which largely take place in hepatocytes and macrophages, produce trace amounts of reactive oxygen species (ROS).In a situation where antioxidants fail to counteract these charged species, patients with neurological disorders such as Parkinson's and Alzheimer's disease may develop. Free radicals and charged species have been demonstrated to be more prevalent in patients with neurological disorders. This is linked to neuronal cell oxidative damage. Thus, in helping with neuroprotection and lessen oxidative stress under these circumstances, antioxidants are frequently employed. Methodology: Five grams of turmeric were weighed and extracted using a Soxhlet apparatus. The extract was evaporated, and the sample was weighed for further calculation. Additionally, four different varieties of turmeric were sampled, weighing 10 gm of turmeric and extracting the extract in 500 millilitres of ethanol. 8 cycles for every sample. The Antioxidant Assay of Extracts (ABTS Assay) is also employed. Moreover, column chromatography was used to purify the extracts. that the fractions chosen for HPLC examination have the highest amount of curcumin.with s modifications aamorphous calcium phosphate nanoparticles using the co precipitation approach from (Xia et al. 2018). and the use of synthesized calcium phosphate nanoparticles to encapsulate curcumin. to treat SHSY-5Y cell line induce with glyceraldehyde and rotenone chemical inducers, Conclusions:These findings provide insights into potential avenues for developing treatments that target the genetic aspects of AD and Parkinson's disease. However, further mechanistic exploration is necessary to fully comprehend the underlying molecular mechanisms and translate these findings into effective clinical strategies for these intricate neurological disorders.